SEC22B explained

Vesicle-trafficking protein SEC22b is a protein that in humans is encoded by the SEC22B gene.^{[1] [2] [3]}

Function

The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It associates with other SNARE proteins to form a SNARE complex and it is thought to play a role in the ER-Golgi protein trafficking. It is required for platelet alpha-granule biogenesis in megakaryocytes^[4] and is essential for the elongated morphology of endothelial cell Weibel-Palade bodies.^[5] This protein has strong similarity to Mus musculus and Cricetulus griseus proteins. There is evidence for use of multiple polyadenylation sites for the transcript. SEC22B has been shown to interact with syntaxin 18^[6] and syntaxin 5.^[7]

Further reading

• Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF . Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes . Journal of Proteome Research . 5 . 11 . 3135–44 . November 2006 . 17081065 . 10.1021/pr060363j .
• Breuza L, Halbeisen R, Jenö P, Otte S, Barlowe C, Hong W, Hauri HP . Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46 . The Journal of Biological Chemistry . 279 . 45 . 47242–53 . November 2004 . 15308636 . 10.1074/jbc.M406644200 . free .
• Nakajima K, Hirose H, Taniguchi M, Kurashina H, Arasaki K, Nagahama M, Tani K, Yamamoto A, Tagaya M . Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion . The EMBO Journal . 23 . 16 . 3216–26 . August 2004 . 15272311 . 514507 . 10.1038/sj.emboj.7600333 .
• Fu GK, Wang JT, Yang J, Au-Young J, Stuve LL . Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes . Genomics . 84 . 1 . 205–10 . July 2004 . 15203218 . 10.1016/j.ygeno.2004.01.011 .
• Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M . Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi . The EMBO Journal . 23 . 6 . 1267–78 . March 2004 . 15029241 . 381410 . 10.1038/sj.emboj.7600135 .
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Research . 10 . 10 . 1546–60 . October 2000 . 11042152 . 310934 . 10.1101/gr.140200 .
• Xu D, Joglekar AP, Williams AL, Hay JC . Subunit structure of a mammalian ER/Golgi SNARE complex . The Journal of Biological Chemistry . 275 . 50 . 39631–9 . December 2000 . 11035026 . 10.1074/jbc.M007684200 . free .
• Parlati F, McNew JA, Fukuda R, Miller R, Söllner TH, Rothman JE . Topological restriction of SNARE-dependent membrane fusion . Nature . 407 . 6801 . 194–8 . September 2000 . 11001058 . 10.1038/35025076 . 2000Natur.407..194P . 4410803 .
• Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z . Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning . Proceedings of the National Academy of Sciences of the United States of America . 95 . 14 . 8175–80 . July 1998 . 9653160 . 20949 . 10.1073/pnas.95.14.8175 . 1998PNAS...95.8175M . free .

Notes and References

1. Hay JC, Chao DS, Kuo CS, Scheller RH . Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells . Cell . 89 . 1 . 149–58 . April 1997 . 9094723 . 10.1016/S0092-8674(00)80191-9 . 8682509 . free .
2. Okumura AJ, Hatsuzawa K, Tamura T, Nagaya H, Saeki K, Okumura F, Nagao K, Nishikawa M, Yoshimura A, Wada I . Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system . The Journal of Biological Chemistry . 281 . 7 . 4495–506 . February 2006 . 16354670 . 10.1074/jbc.M509715200 . free .
3. Web site: Entrez Gene: SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae).
4. Lo . Richard W. . Li . Ling . Pluthero . Fred G. . Leung . Richard . Eto . Koji . Kahr . Walter H. A. . 2020-08-06 . The endoplasmic reticulum protein SEC22B interacts with NBEAL2 and is required for megakaryocyte α-granule biogenesis . Blood . en . 136 . 6 . 715–725 . 10.1182/blood.2019004276 . 0006-4971.
5. Ellie Karampini . Petra E. Bürgisser . Jenny Olins . Aat A. Mulder . Carolina R. Jost . Dirk Geerts . Jan Voorberg . Ruben Bierings . 2020-03-26 . Sec22b determines Weibel-Palade body length by controlling anterograde ER-Golgi transport . Haematologica . 106 . 4 . 1138–1147 . 10.3324/haematol.2019.242727 . 32336681 . 8018124 . 1592-8721.
6. Hatsuzawa . Kiyotaka . Hirose . Hidenori . Tani . Katsuko . Yamamoto . Akitsugu . Scheller . Richard H. . Tagaya . Mitsuo . May 2000 . Syntaxin 18, a SNAP Receptor That Functions in the Endoplasmic Reticulum, Intermediate Compartment, and cis-Golgi Vesicle Trafficking . Journal of Biological Chemistry . 275 . 18 . 13713–13720 . 10.1074/jbc.275.18.13713 . free . 10788491 . 0021-9258.
7. Kat . Marije . Karampini . Ellie . Hoogendijk . Arie J. . Bürgisser . Petra E. . Mulder . Aat A. . Alphen . Floris P. J. van . Olins . Jenny . Geerts . Dirk . Biggelaar . Maartje van den . Margadant . Coert . Voorberg . Jan . Bierings . Ruben . 2022-01-27 . Syntaxin 5 determines Weibel-Palade body size and von Willebrand factor secretion by controlling Golgi architecture . Haematologica . en . 107 . 8 . 1827–1839 . 10.3324/haematol.2021.280121 . 1592-8721 . 9335113 . 35081689.