SEC22A explained

Vesicle-trafficking protein SEC22a is a protein that in humans is encoded by the SEC22A gene.^{[1] [2] [3]}

The protein encoded by this gene belongs to the member of the SEC22 family of vesicle trafficking proteins. This protein has similarity to rat SEC22 and may act in the early stages of the secretory pathway. There is evidence for the use of multiple poly A sites in this gene.

Further reading

• Hay JC, Hirling H, Scheller RH . Mammalian vesicle trafficking proteins of the endoplasmic reticulum and Golgi apparatus . J. Biol. Chem. . 271 . 10 . 5671–9 . 1996 . 8621431 . 10.1074/jbc.271.10.5671 . free .
• Zhang QH, Ye M, Wu XY, etal . Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells . Genome Res. . 10 . 10 . 1546–60 . 2001 . 11042152 . 10.1101/gr.140200 . 310934 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Mancias JD, Goldberg J . The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope . Mol. Cell . 26 . 3 . 403–14 . 2007 . 17499046 . 10.1016/j.molcel.2007.03.017 . free .

Notes and References

1. Hay JC, Chao DS, Kuo CS, Scheller RH . Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells . Cell . 89 . 1 . 149–58 . Apr 1997 . 9094723 . 10.1016/S0092-8674(00)80191-9 . 8682509 . free .
2. Tang BL, Low DY, Hong W . Hsec22c: a homolog of yeast Sec22p and mammalian rsec22a and msec22b/ERS-24 . Biochem Biophys Res Commun . 243 . 3 . 885–91 . Mar 1998 . 9501016 . 10.1006/bbrc.1998.8194 .
3. Web site: Entrez Gene: SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae).