SDZ SER-082 explained

SDZ SER-082 is a drug which acts as a mixed antagonist for the 5-HT2B and 5-HT2C serotonin receptors, with good selectivity over other serotonin receptor subtypes and slight preference for 5-HT2C over 5-HT2B.[1] It has been used in animal studies into the behavioural effects of the different 5-HT2 subtypes,[2] [3] [4] and how they influence the effects of other drugs such as cocaine.[5] [6] [7]

Notes and References

  1. Nozulak J, Kalkman HO, Floersheim P, Hoyer D, Schoeffter P, Buerki HR . (+)-cis-4,5,7a,8,9,10,11,11a-octahydro-7H-10-methylindolo[1,7- bc][2,6]-naphthyridine: a 5-HT2C/2B receptor antagonist with low 5-HT2A receptor affinity . Journal of Medicinal Chemistry . 38 . 1 . 28–33 . January 1995 . 7837236 . 10.1021/jm00001a007 .
  2. Mora PO, Netto CF, Graeff FG . Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by the elevated T-maze . Pharmacology Biochemistry and Behavior . 58 . 4 . 1051–7 . December 1997 . 9408213 . 10.1016/S0091-3057(97)00057-9. 11115355 .
  3. Dave KD, Harvey JA, Aloyo VJ . A novel behavioral model that discriminates between 5-HT2A and 5-HT2C receptor activation . Pharmacology Biochemistry and Behavior . 72 . 1–2 . 371–8 . May 2002 . 11900808 . 10.1016/S0091-3057(01)00767-5. 36921090 .
  4. Hawkins MF, Uzelac SM, Hearn JK, Baumeister AA . Effects of selective serotonin2 ligands on behaviors evoked by stress in the rat . Pharmacology Biochemistry and Behavior . 90 . 4 . 632–9 . October 2008 . 18572227 . 10.1016/j.pbb.2008.05.006 . 25959070 .
  5. Filip M, Bubar MJ, Cunningham KA . Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses . The Journal of Pharmacology and Experimental Therapeutics . 310 . 3 . 1246–54 . September 2004 . 15131246 . 10.1124/jpet.104.068841 . 25809734 .
  6. Filip M . Role of serotonin (5-HT)2 receptors in cocaine self-administration and seeking behavior in rats . Pharmacological Reports . 57 . 1 . 35–46 . 2005 . 15849375 .
  7. Filip M, Bubar MJ, Cunningham KA . Contribution of serotonin (5-HT) 5-HT2 receptor subtypes to the discriminative stimulus effects of cocaine in rats . Psychopharmacology . 183 . 4 . 482–9 . January 2006 . 16261316 . 10.1007/s00213-005-0197-y . 23148827 .

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