SDK2 explained

Protein sidekick-2 is a protein that in humans is encoded by the SDK2 gene.^{[1] [2] [3]}

Function

The protein encoded by this gene is a member of the immunoglobulin superfamily.^[3] The protein contains two immunoglobulin domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the specific function of this superfamily member is not yet known. Evidence for alternative splicing at this gene locus has been observed but the full-length nature of additional variants has not yet been determined.^[4]

Further reading

• Structure and Functions of Sidekicks. 2020. 10.3389/fnmol.2020.00139. 32982686. Yamagata M . Frontiers in Molecular Neuroscience. 13. 139. 7479261 . free .
• Kaufman L, Hayashi K, Ross MJ, Ross MD, Klotman PE . Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy . J Am Soc Nephrol . 15 . 7 . 1721–30 . Jun 2004 . 15213259 . 10.1097/01.ASN.0000128975.28958.C2 . free .
• Zody MC, Garber M, Adams DJ, etal . DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage . Nature . 440 . 7087 . 1045–9 . 2006 . 16625196 . 10.1038/nature04689 . 2610434 . 2006Natur.440.1045Z .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Nagase T, Kikuno R, Ishikawa K, etal . Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 7 . 2 . 143–50 . 2000 . 10819331 . 10.1093/dnares/7.2.143 . free .
• Nguyen DN, Liu Y, Litsky ML, Reinke R . The sidekick gene, a member of the immunoglobulin superfamily, is required for pattern formation in the Drosophila eye . Development . 124 . 17 . 3303–12 . 1997 . 10.1242/dev.124.17.3303 . 9310325 .

Notes and References

1. Web site: OMIM: SIDEKICK CELL ADHESION MOLECULE 2; SDK2.
2. Yamagata M, Weiner JA, Sanes JR . Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina . Cell . 110 . 5 . 649–60 . Sep 2002 . 12230981 . 10.1016/S0092-8674(02)00910-8 . 7650760 . free .
3. Structure and Functions of Sidekicks. 2020. 10.3389/fnmol.2020.00139. 32982686. Yamagata. M.. Frontiers in Molecular Neuroscience. 13. 139. 7479261. free.
4. Web site: Entrez Gene: SDK2 sidekick homolog 2 (chicken).