SDK1 explained

Sidekick cell adhesion molecule 1 is a protein that in humans is encoded by the SDK1 gene.^{[1] [2]}

Function

The protein encoded by this gene is a member of the immunoglobulin superfamily.^[3] The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016].

Further reading

• Structure and Functions of Sidekicks. 2020. 10.3389/fnmol.2020.00139. 32982686. Yamagata M . Frontiers in Molecular Neuroscience. 13. 139. 7479261 . free .
• Kaufman L, Hayashi K, Ross MJ, Ross MD, Klotman PE . Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy . J. Am. Soc. Nephrol. . 15 . 7 . 1721–30 . July 2004 . 15213259 . 10.1097/01.asn.0000128975.28958.c2. free .
• Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y . Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals . Am. J. Hypertens. . 23 . 1 . 70–7 . January 2010 . 19851296 . 10.1038/ajh.2009.190 . free .
• Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y . Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals . Am. J. Hypertens. . 23 . 1 . 70–7 . January 2010 . 19851296 . 10.1038/ajh.2009.190 . free .
• Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y . Association of genetic variants with hemorrhagic stroke in Japanese individuals . Int. J. Mol. Med. . 25 . 4 . 649–56 . April 2010 . 20198315 . 10.3892/ijmm_00000388. free .
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
• Saus E, Brunet A, Armengol L, Alonso P, Crespo JM, Fernández-Aranda F, Guitart M, Martín-Santos R, Menchón JM, Navinés R, Soria V, Torrens M, Urretavizcaya M, Vallès V, Gratacòs M, Estivill X . Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients . J Psychiatr Res . 44 . 14 . 971–8 . October 2010 . 20398908 . 10.1016/j.jpsychires.2010.03.007 .
• Kaufman L, Potla U, Coleman S, Dikiy S, Hata Y, Kurihara H, He JC, D'Agati VD, Klotman PE . Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis . J. Biol. Chem. . 285 . 33 . 25677–85 . August 2010 . 20562105 . 2919131 . 10.1074/jbc.M110.133959 . free .
• Cadby G, Mukherjee S, Musk AW, Reid A, Garlepp M, Dick I, Robinson C, Hui J, Fiorito G, Guarrera S, Beilby J, Melton PE, Moses EK, Ugolini D, Mirabelli D, Bonassi S, Magnani C, Dianzani I, Matullo G, Robinson B, Creaney J, Palmer LJ . A genome-wide association study for malignant mesothelioma risk . Lung Cancer . 82 . 1 . 1–8 . October 2013 . 23827383 . 10.1016/j.lungcan.2013.04.018 . 11567/604944 .

Notes and References

1. Web site: Entrez Gene: Sidekick cell adhesion molecule 1. 2018-05-31.
2. Web site: OMIM: SIDEKICK CELL ADHESION MOLECULE 1; SDK1.
3. Structure and Functions of Sidekicks. 2020. 10.3389/fnmol.2020.00139. 32982686. Yamagata. M. Frontiers in Molecular Neuroscience. 13. 139. 7479261. free.