Syndecan-3 Explained

Syndecan-3 is a protein that in humans is encoded by the SDC3 gene.^{[1] [2] [3]}

Further reading

• Barillari G, Gendelman R, Gallo RC, Ensoli B . The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence. . Proc. Natl. Acad. Sci. U.S.A. . 90 . 17 . 7941–5 . 1993 . 7690138 . 10.1073/pnas.90.17.7941 . 47263 . 1993PNAS...90.7941B . free .
• Raulo E, Chernousov MA, Carey DJ, etal . Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3). . J. Biol. Chem. . 269 . 17 . 12999–3004 . 1994 . 10.1016/S0021-9258(18)99975-8 . 8175719 . free .
• Chernousov MA, Carey DJ . N-syndecan (syndecan 3) from neonatal rat brain binds basic fibroblast growth factor. . J. Biol. Chem. . 268 . 22 . 16810–4 . 1993 . 10.1016/S0021-9258(19)85488-1 . 8344959 . free .
• Albini A, Benelli R, Presta M, etal . HIV-tat protein is a heparin-binding angiogenic growth factor. . Oncogene . 12 . 2 . 289–97 . 1996 . 8570206 .
• Chernousov MA, Stahl RC, Carey DJ . Schwann cells secrete a novel collagen-like adhesive protein that binds N-syndecan. . J. Biol. Chem. . 271 . 23 . 13844–53 . 1996 . 8662884 . 10.1074/jbc.271.23.13844 . free .
• Nakanishi T, Kadomatsu K, Okamoto T, etal . Expression of syndecan-1 and -3 during embryogenesis of the central nervous system in relation to binding with midkine. . J. Biochem. . 121 . 2 . 197–205 . 1997 . 9089390 .
• Rusnati M, Coltrini D, Oreste P, etal . Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size. . J. Biol. Chem. . 272 . 17 . 11313–20 . 1997 . 9111037 . 10.1074/jbc.272.17.11313 . free .
• Chang HC, Samaniego F, Nair BC, etal . HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region. . AIDS . 11 . 12 . 1421–31 . 1997 . 9342064 . 10.1097/00002030-199712000-00006 . 7648619 . free .
• Asundi VK, Carey DJ . Phosphorylation of recombinant N-syndecan (syndecan 3) core protein. . Biochem. Biophys. Res. Commun. . 240 . 2 . 502–6 . 1997 . 9388509 . 10.1006/bbrc.1997.7684 .
• Seki N, Ohira M, Nagase T, etal . Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. . DNA Res. . 4 . 5 . 345–9 . 1998 . 9455484 . 10.1093/dnares/4.5.345 . free .
• Kinnunen T, Kaksonen M, Saarinen J, etal . Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth. . J. Biol. Chem. . 273 . 17 . 10702–8 . 1998 . 9553134 . 10.1074/jbc.273.17.10702 . free .
• Hsueh YP, Sheng M . Regulated expression and subcellular localization of syndecan heparan sulfate proteoglycans and the syndecan-binding protein CASK/LIN-2 during rat brain development. . J. Neurosci. . 19 . 17 . 7415–25 . 1999 . 10460248 . 10.1523/JNEUROSCI.19-17-07415.1999. 6782500 . free .
• Rusnati M, Tulipano G, Spillmann D, etal . Multiple interactions of HIV-I Tat protein with size-defined heparin oligosaccharides. . J. Biol. Chem. . 274 . 40 . 28198–205 . 1999 . 10497173 . 10.1074/jbc.274.40.28198 . free .
• Tyagi M, Rusnati M, Presta M, Giacca M . Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans. . J. Biol. Chem. . 276 . 5 . 3254–61 . 2001 . 11024024 . 10.1074/jbc.M006701200 . free .
• Koroll M, Rathjen FG, Volkmer H . The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity. . J. Biol. Chem. . 276 . 14 . 10646–54 . 2001 . 11152476 . 10.1074/jbc.M010647200 . free.
• Hakansson S, Jacobs A, Caffrey M . Heparin binding by the HIV-1 tat protein transduction domain. . Protein Sci. . 10 . 10 . 2138–9 . 2001 . 11567105 . 10.1110/ps.23401 . 2374215 .
• Erdman R, Stahl RC, Rothblum K, etal . Schwann cell adhesion to a novel heparan sulfate binding site in the N-terminal domain of alpha 4 type V collagen is mediated by syndecan-3. . J. Biol. Chem. . 277 . 9 . 7619–25 . 2002 . 11751872 . 10.1074/jbc.M111311200 . free .
• Alvarez K, Fadic R, Brandan E . Augmented synthesis and differential localization of heparan sulfate proteoglycans in Duchenne muscular dystrophy. . J. Cell. Biochem. . 85 . 4 . 703–13 . 2002 . 11968010 . 10.1002/jcb.10184 . 10533/173369 . 20243469 . free .

Notes and References

1. Carey DJ, Evans DM, Stahl RC, Asundi VK, Conner KJ, Garbes P, Cizmeci-Smith G . Molecular cloning and characterization of N-syndecan, a novel transmembrane heparan sulfate proteoglycan . J Cell Biol . 117 . 1 . 191–201 . May 1992 . 1556152 . 2289399 . 10.1083/jcb.117.1.191 .
2. Berndt C, Casaroli-Marano RP, Vilaro S, Reina M . Cloning and characterization of human syndecan-3 . J Cell Biochem . 82 . 2 . 246–59 . Aug 2001 . 11527150 . 10.1002/jcb.1119 . 1870905 .
3. Web site: Entrez Gene: SDC3 syndecan 3.