| State: | SC |
| Type: | SC |
| Route: | 261 |
| Map: | SC 261 map.svg |
| Length Mi: | 116.960 |
| Length Ref: | [1] [2] [3] [4] [5] |
| Established: | 1926 |
| Direction A: | South |
| Terminus A: | in Yauhannah |
| Junction: | |
| Direction B: | North |
| Terminus B: | near Boykin |
| Previous Type: | SC |
| Counties: | Georgetown, Williamsburg, Clarendon, Sumter, Kershaw |
| Previous Route: | 260 |
| Next Type: | SC |
| Next Route: | 262 |
| History: | Completed in 1944 |
South Carolina Highway 261 (SC 261) is a 116.96miles state highway in the U.S. state of South Carolina. It travels between Yauhannah in Georgetown County to Kershaw County. Although the highway covers more east–west distance, it is signed north–south.
SC 261 begins at U.S. Route 701 (US 701) at Yauhannah in Georgetown County. It travels westerly and then turns northward to end at US 521 north of Boykin in Kershaw County.
Three U.S. National Historic Landmarks—the Millford Plantation, Borough House Plantation and Church of the Holy Cross—are located on the highway in the High Hills of Santee region of Sumter County.