SCO-spondin explained

SCO-spondin is a protein that in humans is encoded by the SSPO gene.^{[1] [2] [3]} SCO-spondin is secreted by the subcommissural organ, and contributes to commissural axon growth and the formation of Reissner's fiber, a fibrous aggregation of secreted molecules extending from the subcommissural organ to the end of the spinal cord.^[4]

Further reading

• Meiniel A, Meiniel R, Gonçalves-Mendes N, Creveaux I, Didier R, Dastugue B . The thrombospondin type 1 repeat (TSR) and neuronal differentiation: roles of SCO-spondin oligopeptides on neuronal cell types and cell lines . International Review of Cytology . 230 . 1–39 . 2004 . 14692680 . 10.1016/S0074-7696(03)30001-4 .
• Meiniel O, Meiniel A . The complex multidomain organization of SCO-spondin protein is highly conserved in mammals . Brain Research Reviews . 53 . 2 . 321–7 . February 2007 . 17126404 . 10.1016/j.brainresrev.2006.09.007 . 7833761 .
• Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Research . 5 . 1 . 31–9 . February 1998 . 9628581 . 10.1093/dnares/5.1.31 . free .
• Nakayama M, Kikuno R, Ohara O . Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs . Genome Research . 12 . 11 . 1773–84 . November 2002 . 12421765 . 187542 . 10.1101/gr.406902 .
• Gonçalves-Mendes N, Simon-Chazottes D, Creveaux I, Meiniel A, Guénet JL, Meiniel R . Mouse SCO-spondin, a gene of the thrombospondin type 1 repeat (TSR) superfamily expressed in the brain . Gene . 312 . 263–70 . July 2003 . 12909363 . 10.1016/S0378-1119(03)00622-X .
• Gonçalves-Mendes N, Blanchon L, Meiniel A, Dastugue B, Sapin V . Placental expression of SCO-spondin during mouse and human development . Gene Expression Patterns . 4 . 3 . 309–14 . May 2004 . 15053980 . 10.1016/j.modgep.2003.10.004 .
• Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, Long J, Stern D, Tammana H, Helt G, Sementchenko V, Piccolboni A, Bekiranov S, Bailey DK, Ganesh M, Ghosh S, Bell I, Gerhard DS, Gingeras TR . Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution . Science . 308 . 5725 . 1149–54 . May 2005 . 15790807 . 10.1126/science.1108625 . 2005Sci...308.1149C . 13047538 .

Notes and References

1. Gobron S, Monnerie H, Meiniel R, Creveaux I, Lehmann W, Lamalle D, Dastugue B, Meiniel A . SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation . Journal of Cell Science . 109 (Pt 5) . 1053–61 . May 1996 . 8743952 . 109 . 5 . 10.1242/jcs.109.5.1053 .
2. Gobron S, Creveaux I, Meiniel R, Didier R, Herbet A, Bamdad M, El Bitar F, Dastugue B, Meiniel A . Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth . Glia . 32 . 2 . 177–91 . November 2000 . 11008217 . 10.1002/1098-1136(200011)32:2<177::AID-GLIA70>3.0.CO;2-V . 46625717 . free .
3. Web site: Entrez Gene: SSPO SCO-spondin homolog (Bos taurus).
4. Gobron S, Creveaux I, Meiniel R, Didier R, Dastugue B, Meiniel A . SCO-spondin is evolutionarily conserved in the central nervous system of the chordate phylum . Neuroscience . 88 . 2 . 655–64 . January 1999 . 10197783 . 10.1016/s0306-4522(98)00252-8 . 426154 .