SCH-50911 explained

SCH-50911 is a selective GABAB antagonist.[1] Its main applications are in pharmacology research.

SCH-50911 also acts as an anticonvulsant under normal conditions. SCH-50911 induces acute withdrawal syndrome in GHB-dependent rats, similar to the delirium tremens seen in human alcohol withdrawal, and can precipitate convulsions in GHB-dependent animals.[2]

Notes and References

  1. Blythin DJ, Kuo SC, Shue HJ, McPhail AT, Chapman RW, Kreutner W, Rizzo C, She HS, West R . 6 . Substituted morpholine-2S-acetic acid derivatives: Sch 50911 and related compounds as novel GABAB antagonists. . Bioorganic & Medicinal Chemistry Letters . July 1996 . 6 . 13 . 1529–34 . 10.1016/S0960-894X(96)00267-3 .
  2. Quang LS, Colombo G, Lobina C, Maccioni P, Orru A, Gessa GL, Maher TJ, Carai MA . 6 . Evaluation for the withdrawal syndrome from gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL), and 1,4-butanediol (1,4-BD) in different rat lines . Annals of the New York Academy of Sciences . 1074 . 545–58 . August 2006 . 1 . 17105952 . 10.1196/annals.1369.055 . 2006NYASA1074..545Q . 86383425 .

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