SCH-202,596 explained

SCH-202,596 is a natural product which is a metabolite derived from an Aspergillus fungus. It acts as a selective non-peptide antagonist for the receptor GAL-1, which is usually activated by the neuropeptide galanin. SCH-202,596 is used for scientific research into this still little characterised receptor subtype.^{[1] [2]}

Notes and References

1. Min C, Mierzwa R, Truumees I, King A, Sapidou E, Barrabee E, Terracciano J, Patel MG, Gullo VP, Burrier R, Das PR . 6 . A new fungal metabolite, Sch 202596, with inhibitory activity in the galanin receptor GALR1 assay. . Tetrahedron Letters . September 1997 . 38 . 35 . 6111–4 . 10.1016/S0040-4039(97)01385-3 .
2. Katoh T, Ohmori O, Iwasaki K, Inoue M . Synthetic studies on Sch 202596, an antagonist of the galanin receptor subtype GalR1: an efficient synthesis of (±)-geodin, the spirocoumaranone part of Sch 202596. . Tetrahedron . February 2002 . 58 . 7 . 1289–99 . 10.1016/S0040-4020(01)01250-9 .