Secretagogin Explained

Secretagogin is a protein that in humans is encoded by the SCGN gene.^{[1] [2]}

Function

The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in potassium chloride-stimulated calcium flux and cell proliferation. This protein plays an important role in the release of the stress hormone Corticotropin-releasing hormone (CRH) and which only then enables stress processes in the brain.

Further reading

• Gartner W, Lang W, Leutmetzer F, etal . Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein. . Cereb. Cortex . 11 . 12 . 1161–9 . 2002 . 11709487 . 10.1093/cercor/11.12.1161 . free.
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free.
• Zhan X . Evans CO . Oyesiku NM . Desiderio DM . Proteomics and transcriptomics analyses of secretagogin down-regulation in human non-functional pituitary adenomas. . Pituitary . 6 . 4 . 189–202 . 2004 . 15237930 . 10.1023/B:PITU.0000023426.99808.40 . 29004965.
• Zierhut B, Daneva T, Gartner W, etal . Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene. . Biochem. Biophys. Res. Commun. . 329 . 4 . 1193–9 . 2005 . 15766553 . 10.1016/j.bbrc.2005.02.093.
• Skovhus KV, Bergholdt R, Erichsen C, etal . Identification and characterization of secretagogin promoter activity. . Scand. J. Immunol. . 64 . 6 . 639–45 . 2007 . 17083620 . 10.1111/j.1365-3083.2006.01854.x . 13567265 . free.
• Romanov R. . Alpar A. . A secretagogin locus of the mammalian hypothalamus controls stress hormone release. . EMBO Journal . 2014 . 10.15252/embj.201488977 . etal . 34 . 1 . 36–54 . 4291479 . 25430741.
• Téllez de Meneses . Pablo G. . Pérez-Revuelta . Laura . Canal-Alonso . Ángel . Hernández-Pérez . Carlos . Cocho . Teresa . Valero . Jorge . Weruaga . Eduardo . Díaz . David . Alonso . José R. . 2023 . Immunohistochemical distribution of secretagogin in the mouse brain . Frontiers in Neuroanatomy . 17 . 10.3389/fnana.2023.1224342. free . 37711587 . 10498459 .

Notes and References

1. Wagner L . Oliyarnyk O . Gartner W . Nowotny P . Groeger M . Kaserer K . Waldhausl W . Pasternack MS . Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein . J Biol Chem . 275 . 32 . 24740–51 . Sep 2000 . 10811645 . 10.1074/jbc.M001974200 . free .
2. Web site: Entrez Gene: SCGN secretagogin, EF-hand calcium binding protein.