SCGB3A1 explained

Secretoglobin family 3A member 1 is a protein that in humans is encoded by the SCGB3A1 gene.^{[1] [2]}

Further reading

• Porter D, Lahti-Domenici J, Torres-Arzayus M, Chin L, Polyak K . Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues . Mechanisms of Development . 114 . 1–2 . 201–4 . June 2002 . 12175512 . 10.1016/S0925-4773(02)00056-4 . 1770009 .
• Reynolds SD, Reynolds PR, Pryhuber GS, Finder JD, Stripp BR . Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways . American Journal of Respiratory and Critical Care Medicine . 166 . 11 . 1498–509 . December 2002 . 12406855 . 10.1164/rccm.200204-285OC .
• Niimi T, Copeland NG, Gilbert DJ, Jenkins NA, Srisodsai A, Zimonjic DB, Keck-Waggoner CL, Popescu NC, Kimura S . Cloning, expression, and chromosomal localization of the mouse gene (Scgb3a1, alias Ugrp2) that encodes a member of the novel uteroglobin-related protein gene family . Cytogenetic and Genome Research . 97 . 1–2 . 120–7 . 2003 . 12438750 . 10.1159/000064067 . 37313915 .
• Krop I, Maguire P, Lahti-Domenici J, Lodeiro G, Richardson A, Johannsdottir HK, Nevanlinna H, Borg A, Gelman R, Barkardottir RB, Lindblom A, Polyak K . Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors . Cancer Research . 63 . 9 . 2024–7 . May 2003 . 12727813 .
• Bin LH, Nielson LD, Liu X, Mason RJ, Shu HB . Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair . Journal of Immunology . 171 . 2 . 924–30 . July 2003 . 12847263 . 10.4049/jimmunol.171.2.924 . free .
• Fackler MJ, McVeigh M, Evron E, Garrett E, Mehrotra J, Polyak K, Sukumar S, Argani P . DNA methylation of RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma . International Journal of Cancer . 107 . 6 . 970–5 . December 2003 . 14601057 . 10.1002/ijc.11508 . 43639879 . free .
• Tisserand P, Fouquet C, Barrois M, Gallou C, Dendale R, Stoppa-Lyonnet D, Sastre-Garau X, Fourquet A, Soussi T . Lack of HIN-1 methylation defines specific breast tumor subtypes including medullary carcinoma of the breast and BRCA1-linked tumors . Cancer Biology & Therapy . 2 . 5 . 559–63 . 2004 . 14614327 . 10.4161/cbt.2.5.511 . 25141850 .
• Marchetti A, Barassi F, Martella C, Chella A, Salvatore S, Castrataro A, Mucilli F, Sacco R, Buttitta F . Down regulation of high in normal-1 (HIN-1) is a frequent event in stage I non-small cell lung cancer and correlates with poor clinical outcome . Clinical Cancer Research . 10 . 4 . 1338–43 . February 2004 . 14977834 . 10.1158/1078-0432.CCR-1174-03 . free .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites . Protein Science . 13 . 10 . 2819–24 . October 2004 . 15340161 . 2286551 . 10.1110/ps.04682504 .
• Krop I, Player A, Tablante A, Taylor-Parker M, Lahti-Domenici J, Fukuoka J, Batra SK, Papadopoulos N, Richards WG, Sugarbaker DJ, Wright RL, Shim J, Stamey TA, Sellers WR, Loda M, Meyerson M, Hruban R, Jen J, Polyak K . Frequent HIN-1 promoter methylation and lack of expression in multiple human tumor types . Molecular Cancer Research . 2 . 9 . 489–94 . September 2004 . 10.1158/1541-7786.489.2.9 . 15383627 . 25730252 . free .
• Shigematsu H, Suzuki M, Takahashi T, Miyajima K, Toyooka S, Shivapurkar N, Tomlinson GE, Mastrangelo D, Pass HI, Brambilla E, Sathyanarayana UG, Czerniak B, Fujisawa T, Shimizu N, Gazdar AF . Aberrant methylation of HIN-1 (high in normal-1) is a frequent event in many human malignancies . International Journal of Cancer . 113 . 4 . 600–4 . February 2005 . 15472908 . 10.1002/ijc.20622 . 1168580 . free .
• Krop I, Parker MT, Bloushtain-Qimron N, Porter D, Gelman R, Sasaki H, Maurer M, Terry MB, Parsons R, Polyak K . HIN-1, an inhibitor of cell growth, invasion, and AKT activation . Cancer Research . 65 . 21 . 9659–69 . November 2005 . 16266985 . 10.1158/0008-5472.CAN-05-1663 . free .
• Yang Q, Kiernan CM, Tian Y, Salwen HR, Chlenski A, Brumback BA, London WB, Cohn SL . Methylation of CASP8, DCR2, and HIN-1 in neuroblastoma is associated with poor outcome . Clinical Cancer Research . 13 . 11 . 3191–7 . June 2007 . 17545522 . 10.1158/1078-0432.CCR-06-2846 . 13614534 .
• Wu Q, Lothe RA, Ahlquist T, Silins I, Tropé CG, Micci F, Nesland JM, Suo Z, Lind GE . DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets . Molecular Cancer . 6 . 45 . July 2007 . 17623056 . 1964763 . 10.1186/1476-4598-6-45 . free .

Notes and References

1. Krop IE, Sgroi D, Porter DA, Lunetta KL, LeVangie R, Seth P, Kaelin CM, Rhei E, Bosenberg M, Schnitt S, Marks JR, Pagon Z, Belina D, Razumovic J, Polyak K . HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells . Proceedings of the National Academy of Sciences of the United States of America . 98 . 17 . 9796–801 . August 2001 . 11481438 . 55532 . 10.1073/pnas.171138398 . 2001PNAS...98.9796K . free .
2. Web site: Entrez Gene: SCGB3A1 secretoglobin, family 3A, member 1.