SCG3 explained

Secretogranin III, also known as SCG3, is a protein which in humans is encoded by the SCG3 gene.^{[1] [2]}

Function

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown.

Further reading

• Huttner WB, Gerdes HH, Rosa P . The granin (chromogranin/secretogranin) family . Trends in Biochemical Sciences . 16 . 1 . 27–30 . January 1991 . 2053134 . 10.1016/0968-0004(91)90012-K .
• Ozawa H, Takata K . The granin family--its role in sorting and secretory granule formation . Cell Structure and Function . 20 . 6 . 415–20 . December 1995 . 8825061 . 10.1247/csf.20.415 . free .
• Dopazo A, Lovenberg TW, Danielson PE, Ottiger HP, Sutcliffe JG . Primary structure of mouse secretogranin III and its absence from deficient mice . Journal of Molecular Neuroscience . 4 . 4 . 225–33 . 1994 . 7917832 . 10.1007/BF02821554 . 6030810 .
• Holthuis JC, Jansen EJ, Martens GJ . Secretogranin III is a sulfated protein undergoing proteolytic processing in the regulated secretory pathway . The Journal of Biological Chemistry . 271 . 30 . 17755–60 . July 1996 . 8663421 . 10.1074/jbc.271.30.17755 . free . 2066/29535 . free .
• Rong YP, Liu F, Zeng LC, Ma WJ, Wei DZ, Han ZG . Cloning and characterization of a novel human secretory protein: secretogranin III . Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica . 34 . 4 . 411–7 . July 2002 . 12098761 .
• Hosaka M, Watanabe T, Sakai Y, Uchiyama Y, Takeuchi T . Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells . Molecular Biology of the Cell . 13 . 10 . 3388–99 . October 2002 . 12388744 . 129953 . 10.1091/mbc.02-03-0040 .
• Sakai Y, Hosaka M, Hira Y, Harumi T, Ohsawa Y, Wang H, Takeuchi T, Uchiyama Y, Watanabe T . Immunocytochemical localization of secretogranin III in the anterior lobe of male rat pituitary glands . The Journal of Histochemistry and Cytochemistry . 51 . 2 . 227–38 . February 2003 . 12533531 . 10.1177/002215540305100211 . free .
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment . Genome Research . 13 . 10 . 2265–70 . October 2003 . 12975309 . 403697 . 10.1101/gr.1293003 .
• Hosaka M, Suda M, Sakai Y, Izumi T, Watanabe T, Takeuchi T . Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A . The Journal of Biological Chemistry . 279 . 5 . 3627–34 . January 2004 . 14597614 . 10.1074/jbc.M310104200 . free .
• Sakai Y, Hosaka M, Yoshinaga A, Hira Y, Harumi T, Watanabe T . Immunocytochemical localization of secretogranin III in the endocrine pancreas of male rats . Archives of Histology and Cytology . 67 . 1 . 57–64 . March 2004 . 15125023 . 10.1679/aohc.67.57 . free .
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries . DNA Research . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Tanabe A, Yanagiya T, Iida A, Saito S, Sekine A, Takahashi A, Nakamura T, Tsunoda T, Kamohara S, Nakata Y, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Funahashi T, Miyazaki S, Tokunaga K, Hamaguchi K, Shimada T, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y, Hotta K . Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity . The Journal of Clinical Endocrinology and Metabolism . 92 . 3 . 1145–54 . March 2007 . 17200173 . 10.1210/jc.2006-1808 . free .

Notes and References

1. Rong YP, Liu F, Zeng LC, Ma WJ, Wei DZ, Han ZG . Cloning and characterization of a novel human secretory protein: secretogranin III . Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica . 34 . 4 . 411–7 . July 2002 . 12098761 . 2009-04-05 . 2011-07-21 . https://web.archive.org/web/20110721184218/http://www.abbs.info/fulltxt/eng/34040411.htm . dead .
2. Web site: Entrez Gene: SCG3 secretogranin III.