SCAND1 explained

SCAN domain-containing protein 1 is a protein that in humans is encoded by the SCAND1 gene.^{[1] [2] [3] [4]}

Function

The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 amino acids originally found within a subfamily of zinc finger proteins. This gene belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. Functional studies have established that the SCAN box is a protein interaction domain that mediates both hetero- and homoprotein associations, and maybe involved in regulation of transcriptional activity. Two transcript variants with different 5' UTRs, but encoding the same protein, have been described for this gene.

Interactions

SCAND1 has been shown to interact with MZF1.

Further reading

• Williams AJ, Blacklow SC, Collins T . The zinc finger-associated SCAN box is a conserved oligomerization domain . Molecular and Cellular Biology . 19 . 12 . 8526–35 . Dec 1999 . 10567577 . 84969 . 10.1128/mcb.19.12.8526.
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Research . 10 . 11 . 1788–95 . Nov 2000 . 11076863 . 310948 . 10.1101/gr.143000 .
• Sander TL, Morris JF . Characterization of the SCAN box encoding RAZ1 gene: analysis of cDNA transcripts, expression, and cellular localization . Gene . 296 . 1–2 . 53–64 . Aug 2002 . 12383503 . 10.1016/S0378-1119(02)00792-8 .
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A . From ORFeome to biology: a functional genomics pipeline . Genome Research . 14 . 10B . 2136–44 . Oct 2004 . 15489336 . 528930 . 10.1101/gr.2576704 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S . The LIFEdb database in 2006 . Nucleic Acids Research . 34 . Database issue . D415–8 . Jan 2006 . 16381901 . 1347501 . 10.1093/nar/gkj139 .
• Carneiro FR, Silva TC, Alves AC, Haline-Vaz T, Gozzo FC, Zanchin NI . Spectroscopic characterization of the tumor antigen NY-REN-21 and identification of heterodimer formation with SCAND1 . Biochemical and Biophysical Research Communications . 343 . 1 . 260–8 . Apr 2006 . 16540086 . 10.1016/j.bbrc.2006.02.140 .

Notes and References

1. Sander TL, Haas AL, Peterson MJ, Morris JF . Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations . The Journal of Biological Chemistry . 275 . 17 . 12857–67 . Apr 2000 . 10777584 . 10.1074/jbc.275.17.12857 . free .
2. Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q, Coulis CM, Wang LL, Ballinger D, Bowen BR, Wagner S . The SCAN domain mediates selective oligomerization . The Journal of Biological Chemistry . 275 . 22 . 17173–9 . Jun 2000 . 10747874 . 10.1074/jbc.M000119200 . free .
3. Babb R, Bowen BR . SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain . The Biochemical Journal . 370 . Pt 2 . 719–27 . Mar 2003 . 12444922 . 1223195 . 10.1042/BJ20021378 .
4. Web site: Entrez Gene: SCAND1 SCAN domain containing 1.