SCAMP1 explained

Secretory carrier-associated membrane protein 1 is a protein that in humans is encoded by the SCAMP1 gene.^{[1] [2]}

Function

This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways.

Interactions

SCAMP1 has been shown to interact with ITSN1^[3] and AP1GBP1.^[3]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Brand SH, Castle JD . SCAMP 37, a new marker within the general cell surface recycling system . The EMBO Journal . 12 . 10 . 3753–61 . October 1993 . 8404846 . 413657 . 10.1002/j.1460-2075.1993.tb06053.x.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Analytical Biochemistry . 236 . 1 . 107–13 . April 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Research . 7 . 4 . 353–8 . April 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353 .
• Wu TT, Castle JD . Evidence for colocalization and interaction between 37 and 39 kDa isoforms of secretory carrier membrane proteins (SCAMPs) . Journal of Cell Science . 110 (Pt 13) . 1533–41 . July 1997 . 9224770 . 110 . 13 . 10.1242/jcs.110.13.1533 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z . Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning . Proceedings of the National Academy of Sciences of the United States of America . 95 . 14 . 8175–80 . July 1998 . 9653160 . 20949 . 10.1073/pnas.95.14.8175 . 1998PNAS...95.8175M . free .
• Wu TT, Castle JD . Tyrosine phosphorylation of selected secretory carrier membrane proteins, SCAMP1 and SCAMP3, and association with the EGF receptor . Molecular Biology of the Cell . 9 . 7 . 1661–74 . July 1998 . 9658162 . 25404 . 10.1091/mbc.9.7.1661 .
• Fernández-Chacón R, Achiriloaie M, Janz R, Albanesi JP, Südhof TC . SCAMP1 function in endocytosis . The Journal of Biological Chemistry . 275 . 17 . 12752–6 . April 2000 . 10777571 . 10.1074/jbc.275.17.12752 . free .
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Research . 10 . 10 . 1546–60 . October 2000 . 11042152 . 310934 . 10.1101/gr.140200 .
• Bell AW, Ward MA, Blackstock WP, Freeman HN, Choudhary JS, Lewis AP, Chotai D, Fazel A, Gushue JN, Paiement J, Palcy S, Chevet E, Lafrenière-Roula M, Solari R, Thomas DY, Rowley A, Bergeron JJ . Proteomics characterization of abundant Golgi membrane proteins . The Journal of Biological Chemistry . 276 . 7 . 5152–65 . February 2001 . 11042173 . 10.1074/jbc.M006143200 . free .
• Fernández-Chacón R, Südhof TC . Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic vesicle-specific forms implicate SCAMPs in multiple membrane-trafficking functions . The Journal of Neuroscience . 20 . 21 . 7941–50 . November 2000 . 11050114 . 6772721 . 10.1523/JNEUROSCI.20-21-07941.2000.
• Guo Z, Liu L, Cafiso D, Castle D . Perturbation of a very late step of regulated exocytosis by a secretory carrier membrane protein (SCAMP2)-derived peptide . The Journal of Biological Chemistry . 277 . 38 . 35357–63 . September 2002 . 12124380 . 10.1074/jbc.M202259200 . free .
• Liu L, Guo Z, Tieu Q, Castle A, Castle D . Role of secretory carrier membrane protein SCAMP2 in granule exocytosis . Molecular Biology of the Cell . 13 . 12 . 4266–78 . December 2002 . 12475951 . 138632 . 10.1091/mbc.E02-03-0136 .
• Hillman RT, Green RE, Brenner SE . An unappreciated role for RNA surveillance . Genome Biology . 5 . 2 . R8 . 2005 . 14759258 . 395752 . 10.1186/gb-2004-5-2-r8 . free .
• Lin PJ, Williams WP, Luu Y, Molday RS, Orlowski J, Numata M . Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7 . Journal of Cell Science . 118 . Pt 9 . 1885–97 . May 2005 . 15840657 . 10.1242/jcs.02315 . free .

Notes and References

1. Singleton DR, Wu TT, Castle JD . Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions . Journal of Cell Science . 110 (Pt 17) . 2099–107 . September 1997 . 9378760 . 110 . 17 . 10.1242/jcs.110.17.2099 .
2. Web site: Entrez Gene: SCAMP1 secretory carrier membrane protein 1.
3. Fernández-Chacón R, Achiriloaie M, Janz R, Albanesi JP, Südhof TC . SCAMP1 function in endocytosis . The Journal of Biological Chemistry . 275 . 17 . 12752–6 . April 2000 . 10777571 . 10.1074/jbc.275.17.12752 . free .