SB-649,915 explained

SB-649,915 is a serotonin reuptake inhibitor and 5-HT_1A and 5-HT_1B receptor antagonist which is being investigated for its antidepressant effects.^[1] Relative to the selective serotonin reuptake inhibitors (SSRIs), SB-649,915 has a faster onset of action and may also have greater clinical efficacy as well. This can be attributed to blockade of 5-HT_1A and 5-HT_1B autoreceptors which inhibit serotonin release.

See also

• Elzasonan
• LY-367,265

Notes and References

1. Starr KR, Price GW, Watson JM, Atkinson PJ, Arban R, Melotto S, Dawson LA, Hagan JJ, Upton N, Duxon MS . SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test. . Neuropsychopharmacology . 32 . 10 . 2163–2172. 2007 . 17356576 . 10.1038/sj.npp.1301341 . free .