SB-612,111 explained

SB-612,111 is an opioid receptor ligand which is a potent and selective antagonist for the nociceptin receptor (ORL-1), several times more potent than the older drug J-113,397.^[1] It does not have analgesic effects in its own right, but prevents the development of hyperalgesia,^[2] and also shows antidepressant effects in animal studies.^[3]

See also

• JTC-801
• J-113,397
• LY-2940094

Notes and References

1. Spagnolo B, Carrà G, Fantin M, Fischetti C, Hebbes C, McDonald J, Barnes TA, Rizzi A, Trapella C, Fanton G, Morari M, Lambert DG, Regoli D, Calò G . 6 . Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vitro studies . The Journal of Pharmacology and Experimental Therapeutics . 321 . 3 . 961–7 . June 2007 . 17329552 . 10.1124/jpet.106.116764 . 17504101 .
2. Zaratin PF, Petrone G, Sbacchi M, Garnier M, Fossati C, Petrillo P, Ronzoni S, Giardina GA, Scheideler MA . 6 . Modification of nociception and morphine tolerance by the selective opiate receptor-like orphan receptor antagonist (-)-cis-1-methyl-7-4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111) . The Journal of Pharmacology and Experimental Therapeutics . 308 . 2 . 454–61 . February 2004 . 14593080 . 10.1124/jpet.103.055848 . 8036750 .
3. Rizzi A, Gavioli EC, Marzola G, Spagnolo B, Zucchini S, Ciccocioppo R, Trapella C, Regoli D, Calò G . 6 . Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vivo studies . The Journal of Pharmacology and Experimental Therapeutics . 321 . 3 . 968–74 . June 2007 . 17329551 . 10.1124/jpet.106.116780 . 2557475 .