SB-357134 explained

SB-357134 is a drug which is used in scientific research. It acts as a potent, selective and orally active 5-HT₆ receptor antagonist.^[1] SB-357134 and other 5-HT₆ antagonists show nootropic effects in animal studies,^{[2] [3] [4]} and have been proposed as potential novel treatments for cognitive disorders such as schizophrenia and Alzheimer's disease.

Notes and References

1. Bromidge SM, Clarke SE, Gager T, Griffith K, Jeffrey P, Jennings AJ, Joiner GF, King FD, Lovell PJ, Moss SF, Newman H, Riley G, Rogers D, Routledge C, Serafinowska H, Smith DR . 6 . Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134) . Bioorganic & Medicinal Chemistry Letters . 11 . 1 . 55–8 . January 2001 . 11140733 . 10.1016/S0960-894X(00)00597-7 .
2. Rogers DC, Hagan JJ . 5-HT6 receptor antagonists enhance retention of a water maze task in the rat . Psychopharmacology . 158 . 2 . 114–9 . November 2001 . 11702084 . 10.1007/s002130100840 . 29472459 .
3. Stean TO, Hirst WD, Thomas DR, Price GW, Rogers D, Riley G, Bromidge SM, Serafinowska HT, Smith DR, Bartlett S, Deeks N, Duxon M, Upton N . 6 . Pharmacological profile of SB-357134: a potent, selective, brain penetrant, and orally active 5-HT(6) receptor antagonist . Pharmacology, Biochemistry, and Behavior . 71 . 4 . 645–54 . April 2002 . 11888556 . 10.1016/S0091-3057(01)00742-0 . 34925312 .
4. Perez-García G, Meneses A . Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task . Pharmacology, Biochemistry, and Behavior . 81 . 3 . 673–82 . July 2005 . 15964617 . 10.1016/j.pbb.2005.05.005 . 19789219 .