SB-228357 explained

SB-228357 is a drug which acts as an antagonist for the 5HT2B and 5HT2C receptors. It has antidepressant and anxiolytic effects in animal models,[1] [2] and inhibits 5-HT2B mediated proliferation of cardiac fibroblasts.[3]

See also

Notes and References

  1. Reavill C, Kettle A, Holland V, Riley G, Blackburn TP . Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist . British Journal of Pharmacology . 126 . 3 . 572–4 . February 1999 . 10188965 . 1565856 . 10.1038/sj.bjp.0702350 .
  2. Bromidge SM, Dabbs S, Davies DT, Davies S, Duckworth DM, Forbes IT, Gaster LM, Ham P, Jones GE, King FD, Mulholland KR, Saunders DV, Wyman PA, Blaney FE, Clarke SE, Blackburn TP, Holland V, Kennett GA, Lightowler S, Middlemiss DN, Trail B, Riley GJ, Wood MD . 6 . Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-2-[(2-methyl-3-pyridyl)oxy]- 5-pyridylcarbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent | journal = Journal of Medicinal Chemistry | volume = 43 | issue = 6 | pages = 1123–34 | date = March 2000 | pmid = 10737744 | doi = 10.1021/jm990388c .
  3. Hutcheson JD, Ryzhova LM, Setola V, Merryman WD . 5-HT(2B) antagonism arrests non-canonical TGF-β1-induced valvular myofibroblast differentiation . Journal of Molecular and Cellular Cardiology . 53 . 5 . 707–14 . November 2012 . 22940605 . 3472096 . 10.1016/j.yjmcc.2012.08.012 .

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