SB-204070 explained
SB-204070 is a drug which acts as a potent and selective 5-HT4 serotonin receptor antagonist (or weak partial agonist), and is used for research into the function of this receptor subtype.[1] [2] [3] [4] [5]
Notes and References
- Mialet J, Berque-Bestel I, Sicsic S, Langlois M, Fischmeister R, Lezoualc'h F . Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells . British Journal of Pharmacology . 131 . 4 . 827–35 . October 2000 . 11030734 . 1572397 . 10.1038/sj.bjp.0703641 .
- Pindon A, van Hecke G, van Gompel P, Lesage AS, Leysen JE, Jurzak M . Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai/o-proteins . Molecular Pharmacology . 61 . 1 . 85–96 . January 2002 . 11752209 . 10.1124/mol.61.1.85 . 85908752 .
- Takahashi H, Takada Y, Urano T, Takada A . 5-HT4 receptors in the hippocampus modulate rat locomotor activity . Hippocampus . 12 . 3 . 304–10 . 2002 . 12099482 . 10.1002/hipo.10012 . 19746691 .
- Sakurai-Yamashita Y, Yamashita K, Niwa M, Taniyama K . Involvement of 5-hydroxytryptamine4 receptor in the exacerbation of neuronal loss by psychological stress in the hippocampus of SHRSP with a transient ischemia . Brain Research . 973 . 1 . 92–8 . May 2003 . 12729957 . 10.1016/S0006-8993(03)02559-9 . 22136959 .
- Smith AJ, Chappell AE, Buret AG, Barrett KE, Dong H . 5-Hydroxytryptamine contributes significantly to a reflex pathway by which the duodenal mucosa protects itself from gastric acid injury . FASEB Journal . 20 . 14 . 2486–95 . December 2006 . 17142798 . 10.1096/fj.06-6391com . free . 27119792 .
