SAV1 explained

Protein salvador homolog 1 is a protein that in humans is encoded by the SAV1 gene.^{[1] [2]}

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a coiled-coil region. It is ubiquitously expressed in adult tissues. The encoded protein is 94% identical to the mouse protein at the amino acid level.^[3]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Yoo NJ, Soung YH, Lee JW, etal . Mutational analysis of salvador gene in human carcinomas . APMIS . 111 . 6 . 595–8 . 2003 . 12969014 . 10.1034/j.1600-0463.2003.1110601.x . 43269337 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Chan EH, Nousiainen M, Chalamalasetty RB, etal . The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1 . Oncogene . 24 . 12 . 2076–86 . 2005 . 15688006 . 10.1038/sj.onc.1208445 . 27285160 .
• Benzinger A, Muster N, Koch HB, etal . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer . Mol. Cell. Proteomics . 4 . 6 . 785–95 . 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . free .
• Callus BA, Verhagen AM, Vaux DL . Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation . FEBS J. . 273 . 18 . 4264–76 . 2006 . 16930133 . 10.1111/j.1742-4658.2006.05427.x . 8261982 .

Notes and References

1. Tapon N, Harvey KF, Bell DW, Wahrer DC, Schiripo TA, Haber DA, Hariharan IK . salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines . Cell . 110 . 4 . 467–78 . Aug 2002 . 12202036 . 10.1016/S0092-8674(02)00824-3 . free .
2. Valverde P . Cloning, expression, and mapping of hWW45, a novel human WW domain-containing gene . Biochem Biophys Res Commun . 276 . 3 . 990–8 . Oct 2000 . 11027580 . 10.1006/bbrc.2000.3582 . 22968498 .
3. Web site: SAV1 salvador family WW domain containing protein 1 [Homo sapiens (human) ]].