SAP130 explained

Histone deacetylase complex subunit SAP130 is an enzyme that in humans is encoded by the SAP130 gene.^{[1] [2] [3]}

Function

SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003).[supplied by OMIM]^[3]

Interactions

SAP130 has been shown to interact with:

• CSN1S1,^[4]
• CUL2,^[4]
• Myc,^[5]
• SIN3A, and
• Von Hippel–Lindau tumor suppressor^[4] and

Further reading

• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Research . 10 . 11 . 1788–95 . Nov 2000 . 11076863 . 310948 . 10.1101/gr.143000 .
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . EMBO Reports . 1 . 3 . 287–92 . Sep 2000 . 11256614 . 1083732 . 10.1093/embo-reports/kvd058 .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . Functional proteomics mapping of a human signaling pathway . Genome Research . 14 . 7 . 1324–32 . Jul 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A . From ORFeome to biology: a functional genomics pipeline . Genome Research . 14 . 10B . 2136–44 . Oct 2004 . 15489336 . 528930 . 10.1101/gr.2576704 .
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S . The LIFEdb database in 2006 . Nucleic Acids Research . 34 . Database issue . D415-8 . Jan 2006 . 16381901 . 1347501 . 10.1093/nar/gkj139 .

Notes and References

1. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Research . 11 . 3 . 422–35 . Mar 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
2. Fleischer TC, Yun UJ, Ayer DE . Identification and characterization of three new components of the mSin3A corepressor complex . Molecular and Cellular Biology . 23 . 10 . 3456–67 . May 2003 . 12724404 . 164750 . 10.1128/MCB.23.10.3456-3467.2003 .
3. Web site: Entrez Gene: SAP130 Sin3A-associated protein, 130kDa.
4. Menon S, Tsuge T, Dohmae N, Takio K, Wei N . Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome . BMC Biochemistry . 2008 . 9 . 1 . 18173839 . 2265268 . 10.1186/1471-2091-9-1 . free .
5. Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E . c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation . The Journal of Biological Chemistry . 278 . 22 . 20405–12 . May 2003 . 12660246 . 4031917 . 10.1074/jbc.M211795200 . free .