SAM domain, SH3 domain and nuclear localization signals 1 explained

SAM domain-containing protein SAMSN-1 is a protein that in humans is encoded by the SAMSN1 gene.^[1]

Function

SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains (Claudio et al., 2001 [PubMed 11536050]).

See also

• SASH1

Further reading

• Zhu YX, Benn S, Li ZH, Wei E, Masih-Khan E, Trieu Y, Bali M, McGlade CJ, Claudio JO, Stewart AK . The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades . J. Exp. Med. . 200 . 6 . 737–47 . 2004 . 15381729 . 2211965 . 10.1084/jem.20031816 .
• Yamada H, Yanagisawa K, Tokumaru S, Taguchi A, Nimura Y, Osada H, Nagino M, Takahashi T . Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer . Genes Chromosomes Cancer . 47 . 9 . 810–8 . 2008 . 18523997 . 10.1002/gcc.20582 . 39369334 .
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
• Brandt S, Ellwanger K, Beuter-Gunia C, Schuster M, Hausser A, Schmitz I, Beer-Hammer S . SLy2 targets the nuclear SAP30/HDAC1 complex . Int. J. Biochem. Cell Biol. . 42 . 9 . 1472–81 . 2010 . 20478393 . 10.1016/j.biocel.2010.05.004 .
• von Holleben M, Gohla A, Janssen KP, Iritani BM, Beer-Hammer S . Immunoinhibitory adapter protein Src homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading . J. Biol. Chem. . 286 . 15 . 13489–501 . 2011 . 21296879 . 3075695 . 10.1074/jbc.M110.155184 . free .
• Yan Y, Zhang L, Xu T, Zhou J, Qin R, Chen C, Zou Y, Fu D, Hu G, Chen J, Lu Y . SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme . PLOS ONE . 8 . 11 . e81905 . 2013 . 24278465 . 3838348 . 10.1371/journal.pone.0081905 . 2013PLoSO...881905Y . free .
• Noll JE, Hewett DR, Williams SA, Vandyke K, Kok C, To LB, Zannettino AC . SAMSN1 is a tumor suppressor gene in multiple myeloma . Neoplasia . 16 . 7 . 572–85 . 2014 . 25117979 . 4198825 . 10.1016/j.neo.2014.07.002 .

Notes and References

1. Web site: Entrez Gene: SAM domain, SH3 domain and nuclear localization signals 1. 2017-09-28.