SAMD4A explained
Sterile alpha motif domain containing 4A is a protein that in humans is encoded by the SAMD4A gene.[1]
Function
Sterile alpha motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element, which was named after the Drosophila Smaug protein (Baez and Boccaccio, 2005 [PubMed 16221671]).[supplied by OMIM, Mar 2008].
Further reading
- Baez MV, Boccaccio GL . Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules . J. Biol. Chem. . 280 . 52 . 43131–40 . December 2005 . 16221671 . 10.1074/jbc.M508374200 . free . 20.500.12110/paper_00219258_v280_n52_p43131_Baez . free .
- Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD . Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip . Am. J. Hum. Genet. . 85 . 5 . 628–42 . November 2009 . 19913121 . 2775832 . 10.1016/j.ajhg.2009.10.014 .
- Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
- Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S . Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study . Diabetes Care . 33 . 10 . 2250–3 . October 2010 . 20628086 . 2945168 . 10.2337/dc10-0452 .
Notes and References
- Web site: Entrez Gene: Sterile alpha motif domain containing 4A. 2020-04-16.
