SAE1 explained

SUMO-activating enzyme subunit 1 is a protein that in humans is encoded by the SAE1 gene.^{[1] [2] [3] [4]}

Interactions

SAE1 has been shown to interact with SAE2, the protein product of the gene UBA2.^{[5] [6]}

Further reading

• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Res. . 10 . 10 . 1546–60 . 2000 . 11042152 . 310934 . 10.1101/gr.140200 .
• Tatham MH, Jaffray E, Vaughan OA, Desterro JM, Botting CH, Naismith JH, Hay RT . Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9 . J. Biol. Chem. . 276 . 38 . 35368–74 . 2001 . 11451954 . 10.1074/jbc.M104214200 . free .
• Azuma Y, Tan SH, Cavenagh MM, Ainsztein AM, Saitoh H, Dasso M . Expression and regulation of the mammalian SUMO-1 E1 enzyme . FASEB J. . 15 . 10 . 1825–7 . 2001 . 11481243 . 10.1096/fj.00-0818fje . free . 40471133 .
• Tatham MH, Kim S, Yu B, Jaffray E, Song J, Zheng J, Rodriguez MS, Hay RT, Chen Y . Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation . Biochemistry . 42 . 33 . 9959–69 . 2003 . 12924945 . 10.1021/bi0345283 .
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Komatsu T, Mizusaki H, Mukai T, Ogawa H, Baba D, Shirakawa M, Hatakeyama S, Nakayama KI, Yamamoto H, Kikuchi A, Morohashi K . Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9 . Mol. Endocrinol. . 18 . 10 . 2451–62 . 2004 . 15192080 . 10.1210/me.2004-0173 . free .
• Salinas S, Briançon-Marjollet A, Bossis G, Lopez MA, Piechaczyk M, Jariel-Encontre I, Debant A, Hipskind RA . SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1 . J. Cell Biol. . 165 . 6 . 767–73 . 2004 . 15210726 . 2172397 . 10.1083/jcb.200310136 .
• Lin JY, Ohshima T, Shimotohno K . Association of Ubc9, an E2 ligase for SUMO conjugation, with p53 is regulated by phosphorylation of p53 . FEBS Lett. . 573 . 1–3 . 15–8 . 2004 . 15327968 . 10.1016/j.febslet.2004.07.059 . 34290197 . free .
• Boggio R, Colombo R, Hay RT, Draetta GF, Chiocca S . A mechanism for inhibiting the SUMO pathway . Mol. Cell . 16 . 4 . 549–61 . 2004 . 15546615 . 10.1016/j.molcel.2004.11.007 . free .
• Lois LM, Lima CD . Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1 . EMBO J. . 24 . 3 . 439–51 . 2005 . 15660128 . 548657 . 10.1038/sj.emboj.7600552 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Klenk C, Humrich J, Quitterer U, Lohse MJ . SUMO-1 controls the protein stability and the biological function of phosducin . J. Biol. Chem. . 281 . 13 . 8357–64 . 2006 . 16421094 . 10.1074/jbc.M513703200 . free .
• Li T, Santockyte R, Shen RF, Tekle E, Wang G, Yang DC, Chock PB . A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers . Arch. Biochem. Biophys. . 453 . 1 . 70–4 . 2006 . 16620772 . 10.1016/j.abb.2006.03.002 .
• Pan X, Li H, Zhang P, Jin B, Man J, Tian L, Su G, Zhao J, Li W, Liu H, Gong W, Zhou T, Zhang X . Ubc9 interacts with SOX4 and represses its transcriptional activity . Biochem. Biophys. Res. Commun. . 344 . 3 . 727–34 . 2006 . 16631117 . 10.1016/j.bbrc.2006.03.194 .

Notes and References

1. Desterro JM, Rodriguez MS, Kemp GD, Hay RT . Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1 . J. Biol. Chem. . 274 . 15 . 10618–24 . May 1999 . 10187858 . 10.1074/jbc.274.15.10618 . free .
2. Okuma T, Honda R, Ichikawa G, Tsumagari N, Yasuda H . In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2 . Biochem. Biophys. Res. Commun. . 254 . 3 . 693–8 . Mar 1999 . 9920803 . 10.1006/bbrc.1998.9995 .
3. Gong L, Li B, Millas S, Yeh ET . Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex . FEBS Lett. . 448 . 1 . 185–9 . Jun 1999 . 10217437 . 10.1016/S0014-5793(99)00367-1 . 7756078 . free .
4. Web site: Entrez Gene: SAE1 SUMO1 activating enzyme subunit 1.
5. Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
6. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .