S6:S18 ribosomal protein leader explained

Ribosomal S6:S18 leader
Symbol:S6:S18
Rna Type:Cis-reg
leader
Tax Domain:Bacteria

S6:S18 ribosomal protein leader is a ribosomal protein leader involved in the ribosome biogenesis. It is used as an autoregulatory mechanism to control the concentration of the ribosomal proteins S6:S18 complex. An experimentally confirmed example of such a leader occurs in a wide variety of bacteria,[1] though not all phyla. A S6:S18 ribosomal leader was predicted in Chlorobia,[2] and its predicted structure differs from that of the validated S6:S18 ribosomal leader. This structure is located in the 5′ untranslated regions of mRNAs encoding ribosomal proteins rpsF (S6), the Single-strand DNA-binding protein A (ssbA), S18 (rpsR) and L7/L12 (rpll).[2]

See also

Notes and References

  1. Meyer . M . Ribosomal RNA Mimicry in RNA Regulation of Gene Expression . Microbiol. Spectr. . 6 . 2 . 21 September 2018 . 10.1128/9781683670247.ch7 . 240183858 .
  2. Eckert . I . Weinberg . Z . Discovery of 20 novel ribosomal leader candidates in bacteria and archaea . BMC Microbiology . 20 . 130 . 24 May 2020 . 130 . 10.1186/s12866-020-01823-6 . 32448158 . 7247131 . free .