S1PR3 explained

Sphingosine-1-phosphate receptor 3 also known as S1PR3 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₃.^[1]

Function

This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function.^[1]

Evolution

Paralogues to S1PR3 Gene^[2]

• S1PR1
• S1PR5
• S1PR2
• S1PR4
• LPAR1
• LPAR3
• LPAR2
• CNR1
• MC5R
• GPR6
• GPR12
• MC4R
• CNR2
• GPR3
• MC3R
• MC2R
• GPR119
• MC1R

See also

• Lysophospholipid receptor

Further reading

• Hla T, Lee MJ, Ancellin N, etal . Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors. . Ann. N. Y. Acad. Sci. . 905 . 16–24 . 2000 . 1 . 10818438 . 10.1111/j.1749-6632.2000.tb06534.x . 2000NYASA.905...16H . 19435541 .
• Spiegel S . Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors. . Ann. N. Y. Acad. Sci. . 905 . 54–60 . 2000 . 1 . 10818441 . 10.1111/j.1749-6632.2000.tb06537.x. 2000NYASA.905...54S . 9257870 .
• Watsky MA, Griffith M, Wang DA, Tigyi GJ . Phospholipid growth factors and corneal wound healing. . Ann. N. Y. Acad. Sci. . 905 . 142–58 . 2000 . 1 . 10818450 . 10.1111/j.1749-6632.2000.tb06546.x . 2000NYASA.905..142W . 9789496 .
• Takuwa Y . [Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors] . Tanpakushitsu Kakusan Koso . 47 . 4 Suppl . 496–502 . 2002 . 11915348 .
• Van Koppen CJ, Meyer Zu Heringdorf D, Zhang C, etal . A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils. . Mol. Pharmacol. . 49 . 6 . 956–61 . 1996 . 8649355 .
• Yamaguchi F, Tokuda M, Hatase O, Brenner S . Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9. . Biochem. Biophys. Res. Commun. . 227 . 2 . 608–14 . 1996 . 8878560 . 10.1006/bbrc.1996.1553 .
• An S, Bleu T, Huang W, etal . Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. . FEBS Lett. . 417 . 3 . 279–82 . 1998 . 9409733 . 10.1016/S0014-5793(97)01301-X . 26300053 . free .
• Van Brocklyn JR, Tu Z, Edsall LC, etal . Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218. . J. Biol. Chem. . 274 . 8 . 4626–32 . 1999 . 9988698 . 10.1074/jbc.274.8.4626 . free .
• Zhang Q, Peyruchaud O, French KJ, etal . Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway. . Blood . 93 . 9 . 2984–90 . 1999 . 10216094 . 10.1182/blood.V93.9.2984.
• Ancellin N, Hla T . Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. . J. Biol. Chem. . 274 . 27 . 18997–9002 . 1999 . 10383399 . 10.1074/jbc.274.27.18997 . free .
• Windh RT, Lee MJ, Hla T, etal . Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins. . J. Biol. Chem. . 274 . 39 . 27351–8 . 1999 . 10488065 . 10.1074/jbc.274.39.27351 . free .
• Goetzl EJ, Dolezalova H, Kong Y, etal . Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer. . Cancer Res. . 59 . 20 . 5370–5 . 1999 . 10537322 .
• Lee MJ, Thangada S, Claffey KP, etal . Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. . Cell . 99 . 3 . 301–12 . 1999 . 10555146 . 10.1016/S0092-8674(00)81661-X . 1126846 . free .
• An S, Zheng Y, Bleu T . Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. . J. Biol. Chem. . 275 . 1 . 288–96 . 2000 . 10617617 . 10.1074/jbc.275.1.288 . free .
• Orlati S, Porcelli AM, Hrelia S, etal . Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor. . Arch. Biochem. Biophys. . 375 . 1 . 69–77 . 2000 . 10683250 . 10.1006/abbi.1999.1589 .
• Lee H, Goetzl EJ, An S . Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing. . Am. J. Physiol., Cell Physiol. . 278 . 3 . C612–8 . 2000 . 10712250 . 10.1152/ajpcell.2000.278.3.C612. 10976499 .
• Kimura T, Watanabe T, Sato K, etal . Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3. . Biochem. J. . 348 . 1. 71–6 . 2000 . 10794715 . 10.1042/0264-6021:3480071 . 1221037.

External links

• Web site: Lysophospholipid Receptors: S₁P₃ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-05 . 2016-03-03 . https://web.archive.org/web/20160303214242/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2995 . dead .

Notes and References

1. Web site: Entrez Gene: S1PR3 sphingosine-1-phosphate receptor 3 .
2. Web site: GeneCards®: The Human Gene Database .