S100G explained

See also: Calbindin.

S100 calcium-binding protein G (S100G) is a protein that in humans is encoded by the S100G gene.^{[1] [2] [3]}

This gene encodes calbindin D9K, a vitamin D-dependent calcium-binding protein. This cytosolic protein belongs to a family of calcium-binding proteins that includes calmodulin, parvalbumin, troponin C, and S100 protein. In the intestine, the protein is vitamin D-dependent and its expression correlates with calcium transport activity. The protein may increase Ca²⁺ absorption by buffering Ca²⁺ in the cytoplasm and increase ATP-dependent Ca²⁺ transport in duodenal basolateral membrane vesicles.

Further reading

• Balmain N . Calbindin-D9k. A vitamin-D-dependent, calcium-binding protein in mineralized tissues . Clin. Orthop. Relat. Res. . 265 . 265–76 . 1991 . 2009668 .
• Fleet JC, Hock JM . Identification of osteocalcin mRNA in nonosteoid tissue of rats and humans by reverse transcription-polymerase chain reaction . J. Bone Miner. Res. . 9 . 10 . 1565–73 . 1995 . 7817802 . 10.1002/jbmr.5650091009 . 1687493 .
• Jeung EB, Leung PC, Krisinger J . The human calbindin-D9k gene. Complete structure and implications on steroid hormone regulation . J. Mol. Biol. . 235 . 4 . 1231–8 . 1994 . 8308886 . 10.1006/jmbi.1994.1076 .
• Barley NF, Prathalingam SR, Zhi P, etal . Factors involved in the duodenal expression of the human calbindin-D9k gene . Biochem. J. . 341 . 3. 491–500 . 1999 . 10417310 . 10.1042/0264-6021:3410491 . 1220384 .
• Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Wang L, Klopot A, Freund JN, etal . Control of differentiation-induced calbindin-D9k gene expression in Caco-2 cells by cdx-2 and HNF-1α . Am. J. Physiol. Gastrointest. Liver Physiol. . 287 . 5 . G943–53 . 2004 . 15217781 . 10.1152/ajpgi.00121.2004 . 2701355 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ross MT, Grafham DV, Coffey AJ, etal . The DNA sequence of the human X chromosome . Nature . 434 . 7031 . 325–37 . 2005 . 15772651 . 10.1038/nature03440 . 2665286 . 2005Natur.434..325R .

Notes and References

1. Howard A, Legon S, Spurr NK, Walters JR . Molecular cloning and chromosomal assignment of human calbindin-D9k . Biochem Biophys Res Commun . 185 . 2 . 663–9 . 1992 . 1610358 . 10.1016/0006-291X(92)91676-H .
2. Jeung EB, Krisinger J, Dann JL, Leung PC . Molecular cloning of the full-length cDNA encoding the human calbindin-D9k . FEBS Lett . 307 . 2 . 224–8 . Sep 1992 . 1379540 . 10.1016/0014-5793(92)80772-9 . 27787157 . free .
3. Web site: Entrez Gene: S100G S100 calcium binding protein G.