S100A14 explained

S100 calcium binding protein A14 (S100A14) is a protein that in humans is encoded by the S100A14 gene.^[1]

Function

This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function.^{[2] [3]}

Further reading

• Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW . Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family . Genomics . 25 . 3 . Feb 1995 . 7759097 . 10.1016/0888-7543(95)80005-7 . 638–43.
• Wolf R, Howard OM, Dong HF, Voscopoulos C, Boeshans K, Winston J, Divi R, Gunsior M, Goldsmith P, Ahvazi B, Chavakis T, Oppenheim JJ, Yuspa SH . Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15 . Journal of Immunology . 181 . 2 . Jul 2008 . 18606705 . 10.4049/jimmunol.181.2.1499 . 2435511 . 1499–1506.
• Stemmler S, Nothnagel M, Parwez Q, Petrasch-Parwez E, Epplen JT, Hoffjan S . Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients . International Journal of Immunogenetics . 36 . 4 . Aug 2009 . 19601998 . 10.1111/j.1744-313X.2009.00858.x . 217–22. 38130688 .
• Jin Q, Chen H, Luo A, Ding F, Liu Z . S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE) . PLOS ONE . 6 . 4 . 21559403 . 10.1371/journal.pone.0019375 . 2011 . e19375 . 3084824. 2011PLoSO...619375J . free .
• Büchau AS, Hassan M, Kukova G, Lewerenz V, Kellermann S, Würthner JU, Wolf R, Walz M, Gallo RL, Ruzicka T . S100A15, an antimicrobial protein of the skin: regulation by E. coli through Toll-like receptor 4 . The Journal of Investigative Dermatology . 127 . 11 . Nov 2007 . 17625598 . 10.1038/sj.jid.5700946 . 2596–604. free .
• Sapkota D, Costea DE, Blø M, Bruland O, Lorens JB, Vasstrand EN, Ibrahim SO . S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest . Oral Oncology . 48 . 3 . Mar 2012 . 22032898 . 10.1016/j.oraloncology.2011.10.001 . 219–25.
• Boeshans KM, Wolf R, Voscopoulos C, Gillette W, Esposito D, Mueser TC, Yuspa SH, Ahvazi B . Purification, crystallization and preliminary X-ray diffraction of human S100A15 . Acta Crystallographica Section F . 62 . Pt 5 . May 2006 . 16682778 . 10.1107/S1744309106012838 . 2219979 . 467–470.

Notes and References

1. Web site: Entrez Gene: S100 calcium binding protein A14.
2. Wang HY, Zhang JY, Cui JT, Tan XH, Li WM, Gu J, Lu YY . Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery . Oncology Reports . 23 . 1 . Jan 2010 . 19956863 . 45–52 . 10.3892/or_00000604 . free .
3. Chen H, Yu D, Luo A, Tan W, Zhang C, Zhao D, Yang M, Liu J, Lin D, Liu Z . Functional role of S100A14 genetic variants and their association with esophageal squamous cell carcinoma . Cancer Research . 69 . 8 . Apr 2009 . 19351828 . 10.1158/0008-5472.CAN-08-4231 . 3451–7. free .