S-methyl-5'-thioinosine phosphorylase explained

S-methyl-5'-thioinosine phosphorylase
Ec Number:	2.4.2.44

S-methyl-5'-thioinosine phosphorylase (MTIP, MTI phosphorylase, methylthioinosine phosphorylase) is an enzyme with systematic name S-methyl-5'-thioinosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase.^[1] This enzyme catalyses the following chemical reaction

\rightleftharpoons hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate

The catabolism of 5'-methylthioadenosine in Pseudomonas aeruginosa involves deamination to S-methyl-5'-thioinosine (EC 3.5.4.31, S-methyl-5'-thioadenosine deaminase) and phosphorolysis to hypoxanthine.

Notes and References

1. Guan R, Ho MC, Almo SC, Schramm VL . Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing . Biochemistry . 50 . 7 . 1247–54 . February 2011 . 21197954 . 3040260 . 10.1021/bi101642d .