| S-methyl-5-thioadenosine phosphorylase | |
| Ec Number: | 2.4.2.28 |
| Cas Number: | 61970-06-7 |
| Go Code: | 0017061 |
| Width: | 270 |
In enzymology, a S-methyl-5'-thioadenosine phosphorylase is an enzyme that catalyzes the chemical reaction
S-methyl-5'-thioadenosine + phosphate
\rightleftharpoons
Thus, the two substrates of this enzyme are S-methyl-5'-thioadenosine and phosphate, whereas its two products are adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate.
This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase. Other names in common use include 5'-methylthioadenosine nucleosidase, 5'-deoxy-5'-methylthioadenosine phosphorylase, MTA phosphorylase, MeSAdo phosphorylase, MeSAdo/Ado phosphorylase, methylthioadenosine phosphorylase, methylthioadenosine nucleoside phosphorylase, 5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase, and S-methyl-5-thioadenosine phosphorylase. This enzyme participates in methionine metabolism.
As of late 2007, 20 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,,,,,,,,,,, and .