S-methyl-5'-thioadenosine deaminase explained

S-methyl-5'-thioadenosine deaminase
Ec Number:	3.5.4.31

S-methyl-5'-thioadenosine deaminase (MTA deaminase, 5-methylthioadenosine deaminase) is an enzyme with systematic name S-methyl-5'-thioadenosine amidohydrolase.^[1] This enzyme catalyses the following chemical reaction

S-methyl-5'-thioadenosine + H₂O

\rightleftharpoons 5'-S-methyl-5'-thioinosine + NH₃

The enzyme from Thermotoga maritima also functions as S-adenosylhomocysteine deaminase (EC 3.5.4.28).

Notes and References

1. Hermann JC, Marti-Arbona R, Fedorov AA, Fedorov E, Almo SC, Shoichet BK, Raushel FM . Structure-based activity prediction for an enzyme of unknown function . Nature . 448 . 7155 . 775–9 . August 2007 . 17603473 . 2254328 . 10.1038/nature05981 .