S-Glutathionylation Explained

S-Glutathionylation is the posttranslational modification of protein cysteine residues by the addition of glutathione, the most abundant and important low-molecular-mass thiol within most cell types.^[1]

Protein S-glutathionylation is involved in

• oxidative stress
• nitrosative stress
• preventing irreversible oxidation of protein thiols
• control of cell-signalling pathways by modulating protein function

Notes and References

1. 10.1016/j.tibs.2008.11.002 . Protein S-glutathionylation: A regulatory device from bacteria to humans . 2009 . Dalle-Donne . Isabella . Rossi . Ranieri . Colombo . Graziano . Giustarini . Daniela . Milzani . Aldo . Trends in Biochemical Sciences . 34 . 2 . 85–96 . 19135374.