S-15535 Explained

S-15535 is a phenylpiperazine drug which is a potent and highly selective 5-HT_1A receptor ligand that acts as an agonist and antagonist (weak partial agonist) at the presynaptic and postsynaptic 5-HT_1A receptors, respectively.^{[1] [2] [3] [4]} It has anxiolytic properties.^[5]

See also

• Phenylpiperazine

Notes and References

1. Millan MJ, Rivet JM, Canton H, Lejeune F, Gobert A, Widdowson P, Bervoets K, Brocco M, Peglion JL . S 15535: a highly selective benzodioxopiperazine 5-HT1A receptor ligand which acts as an agonist and an antagonist (weak partial agonist) at presynaptic and postsynaptic sites respectively . Eur J Pharmacol . 230 . 1 . 99–102 . 1993 . 8381359 . 10.1016/0014-2999(93)90416-F .
2. Millan MJ, Canton H, Gobert A, Lejeune F, Rivet JM, Bervoets K, Brocco M, Widdowson P, Mennini T, Audinot V, etal . Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists . J Pharmacol Exp Ther . 268 . 1 . 337–352 . 1994 . 8301575 .
3. Millan MJ, Newman-Tancredi A, Rivet JM, Brocco M, Lacroix P, Audinot V, Cistarelli L, Gobert A . S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity . J Pharmacol Exp Ther . 282 . 1 . 132–147 . 1997 . 9223549 .
4. Lejeune F, Millan MJ . Induction of burst firing in ventral tegmental area dopaminergic neurons by activation of serotonin (5-HT)1A receptors: WAY 100,635-reversible actions of the highly selective ligands, flesinoxan and S 15535 . Synapse . 30 . 2 . 172–180 . 1998 . 9723787 . 10.1002/(SICI)1098-2396(199810)30:2<172::AID-SYN7>3.0.CO;2-9 .
5. 10.1007/s002130000449 . Dekeyne A, Brocco M, Adhumeau A, Gobert A, Millan MJ . The selective serotonin (5-HT)1A receptor ligand, S15535, displays anxiolytic-like effects in the social interaction and Vogel models and suppresses dialysate levels of 5-HT in the dorsal hippocampus of freely-moving rats. A comparison with other anxiolytic agents . Psychopharmacology . 152 . 1 . 55–66 . 2000 . 11041316 . 2511149 .