S-(2-Aminoethyl)isothiuronium bromide hydrobromide explained

S-(2-Aminoethyl)isothiourea dihydrobromide,[1] commonly knwn as AET, is a isothiouronium-group-containing reducing agent with textbook uses as a disulfide reducing agent. Though it does not have a free thiol group (-SH) like 2-mercaptoethanol and dithiothreitol (DTT), it reacts with water to decompose transiently into thiol intermediates that acts on disulfide in a manner to these containing free -SH groups.

Applications

One application of AET is in hematology where red cells are treated with AET to create PNH-like cells.[2]

References

Notes and References

  1. Web site: 2-(2-Aminoethyl)isothiourea dihydrobromide . Pubchem.
  2. Sirchia . G . In-Vitro Lysis of AET-Treated Normal Red Cells (PNH-like Cells) by Normal and Cirrhotic Sera . British Journal of Haematology . 1969 . 17 . 3 . 245–249. 10.1111/j.1365-2141.1969.tb01369.x . 4979897 . 46358253 .

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