| Sédhiou Region | |
| Native Name: | |
| Settlement Type: | Region |
| Image Map1: | Map of the departments of the Sédhiou region of Senegal.png |
| Map Caption1: | Sédhiou région, divided into 3 departments |
| Coordinates: | 12.7°N -48°W |
| Subdivision Type: | Country |
| Subdivision Name: | Senegal |
| Established Title: | Established |
| Established Date: | 2008 |
| Parts Type: | Départements |
| P1: | Bounkiling Department |
| P2: | Goudoump Department |
| P3: | Sédhiou Department |
| Seat Type: | Capital |
| Seat: | Sédhiou |
| Leader Title: | Governor |
| Leader Name: | Cheikh Kane Niane |
| Unit Pref: | Metric |
| Area Total Km2: | 7341 |
| Population Total: | 590,784 |
| Population As Of: | 2023 census |
| Population Density Km2: | auto |
| Timezone: | GMT |
| Utc Offset: | +0 |
Sédhiou Region (retroactively called Middle Casamance) is a region of Senegal located in the southwest of the country in the natural region called Casamance.
It was historically a department of the Kolda Region until 2008.
It is located between the Kolda Region in the east and the Ziguinchor Region in the west.
It also shares borders with the Gambia in the north and Guinea-Bissau in the south.
Sédhiou Region has three departments: