| São Sebastião Museum Museu São Sebastião | |
| Pushpin Map: | Sao Tome |
| Coordinates: | 0.3458°N 6.7394°W |
| Established: | 1566 (fortress) late 1970s (museum) |
| Collections: | culture, local, artistry |
| Location: | São Tomé, São Tomé Island, São Tomé and Príncipe |
| Type: | National Museum |
São Sebastião Museum is a museum, housed in a 16th-century fortress in the city of São Tomé, São Tomé and Príncipe. It lies in the northeastern part of the city centre, at the southeastern end of Ana Chaves Bay. It contains religious art and colonial-era artifacts.[1] The fortress was built in 1566 by the Portuguese in order to protect the port and city of São Tomé against pirate attacks.[2] A lighthouse was established in the fortress in 1866; it was rebuilt in 1928.[3] The fortress was restored at the end of the 1950s.[4]