| Official Name: | São Francisco do Guaporé |
| Settlement Type: | Municipality |
| Pushpin Map: | Brazil |
| Pushpin Map Caption: | Location in Brazil |
| Coordinates: | 12.0522°N -63.5675°W |
| Subdivision Type: | Country |
| Subdivision Name: | Brazil |
| Subdivision Type1: | Region |
| Subdivision Name1: | North |
| Subdivision Type2: | State |
| Subdivision Name2: | Rondônia |
| Subdivision Type3: | Mesoregion |
| Subdivision Type4: | Microregion |
| Subdivision Type5: | Metrop. region |
| Leader Title: | Mayor |
| Population Total: | 20,681 |
| Population As Of: | 2020 [1] |
| Population Density Km2: | auto |
| Timezone1: | AMT |
| Utc Offset1: | -4 |
| Postal Code Type: | Postal code |
| Area Code Type: | Area code |
São Francisco do Guaporé is a municipality located in the Brazilian state of Rondônia. Its population was 20,681 (2020) and its area is 10,960 km2.[2]
The municipality contains 9% of the Serra dos Reis State Park.It contains 86% of the Serra dos Reis A State Park, created in 1996.It holds part of the Guaporé Biological Reserve, a strictly protected conservation unit.