| Sântioana | |
| Pushpin Map: | Romania |
| Subdivision Type1: | Country |
| Subdivision Name1: | Romania |
| Subdivision Type2: | Counties |
| Subdivision Name2: | Mureș County |
| Subdivision Type3: | Villages |
| Subdivision Name3: | Sântioana, Ormeniș, Laslău Mic, Laslău Mare |
| Length: | 16km (10miles) |
| Mouth: | Târnava Mică |
| Mouth Location: | Laslău Mare |
| Mouth Coordinates: | 46.3911°N 24.5402°W |
| Basin Size: | 45km2 |
The Sântioana is a left tributary of the river Târnava Mică in Romania. It discharges into the Târnava Mică in Laslău Mare.[1] Its length is 16km (10miles) and its basin size is 45km2.