| Type: | commune |
| County: | Alba |
| Sântimbru | |
| Leader Name: | Ioan Iancu Popa |
| Leader Party: | PNL |
| Leader Term: | 2020 - 2024 |
| Coordinates: | 46.1333°N 62°W |
| Elevation: | 216 |
| Area Total: | 44.28 |
| Population Total: | auto |
| Postal Code: | 517675 |
| Area Code: | (+40) 02 58 |
Sântimbru (Hungarian: Marosszentimre; German: Sankt Emmerich) is a commune located in Alba County, Transylvania, Romania. It has a population of 3,032 as of 2021, and is composed of five villages: Coșlariu (Koslárd), Dumitra (Demeterpataka), Galtiu (Gáldtő), Sântimbru, and Totoi (Táté).
The commune is situated on the Transylvanian Plateau, at an altitude of . It lies on the banks of the river Mureș; the river Galda flows into the Mureș in Sântimbru.
Following the Mongol invasion of Europe, Transylvanian Saxons settled in Sântimbru in the 13th century. Driven out by the Ottomans in the 16th century, they were replaced by Hungarians, who practised woodcutting. Ethnic Romanians have been in the majority since the 19th century, and today, the inhabitants mainly build bricks and raise poultry.
The village of Totoi has developed a speech form known as Totoiana which consists in the inversion of Romanian words so that other speakers of normal Romanian cannot understand it. It is unique to the village, and it is not spoken in other parts of Sântimbru.[1] [2] [3]
The commune has a Hungarian Reformed church founded by John Hunyadi in 1449.