RyeE RNA explained
| CyaR/Rye RNA |
| Symbol: | CyaR_RyeE |
| Altsymbols: | RyeE |
| Rfam: | RF00112 |
| Rna Type: | Gene
- sRNA
|
| Tax Domain: | Bacteria |
The CyaR RNA (formerly known as RyeE RNA) non-coding RNA was identified in a large scale screen of Escherichia coli and was called candidate 14.[1] The exact 5′ and 3′ ends of this RNA are uncertain. This gene lies between yegQ and orgK in E. coli. This small RNA was shown to be bound by the Hfq protein. This RNA has been renamed as CyaR for (cyclic AMP-activatedRNA). It has been shown that the CyaR RNA acts as a repressor of the porin OmpX.[2] It has also been shown that cyaR expression is tightly controlled by the cyclic AMP receptor protein, CRP.
A comparative genomics approach was able to detect and verify the additional targets ptsI, sdhA and yobF.[3]
See also
Notes and References
- Wassarman . KM . Repoila F . Rosenow C . Storz G . Gottesman S . 2001 . Identification of novel small RNAs using comparative genomics and microarrays . Genes Dev . 15 . 1637–1651 . 11445539 . 10.1101/gad.901001 . 13 . 312727.
- Papenfort K, Pfeiffer V, Lucchini S, Sonawane A, Hinton JC, Vogel J . Systematic deletion of Salmonella small RNA genes identifies CyaR, a conserved CRP-dependent riboregulator of OmpX synthesis . Mol. Microbiol. . 68 . 4 . 890–906 . May 2008 . 18399940 . 10.1111/j.1365-2958.2008.06189.x . 18442940 .
- Wright PR, Richter AS, Papenfort K, Mann M, Vogel J, Hess WR, Backofen R, Georg J . Comparative genomics boosts target prediction for bacterial small RNAs. . Proc Natl Acad Sci U S A . 110. 37. E3487–E3496. 2013 . 23980183 . 10.1073/pnas.1303248110 . 3773804. 2013PNAS..110E3487W . free .
