RyeB RNA explained

SdsR/RyeB RNA
Symbol:	SdsR_RyeB
Rfam:	RF00111
Rna Type:	Gene sRNA
Tax Domain:	Bacteria

The SdsR/RyeB RNA is a non-coding RNA that was identified in a large scale screen of E. coli.^[1] The exact 5′ and 3′ ends of this RNA are uncertain. This RNA overlaps the SraC/RyeA RNA on the opposite strand suggesting that the two may act in a concerted manner. It is transcribed by general stress factor σ^s and is most highly expressed in stationary phase. SdsR/RyeB RNA interacts with Hfq.

The homologous sRNA in S. enterica was shown to regulate synthesis of major porin OmpD.^[2] A study using Salmonella identified 20 targets of this sRNA including transcriptional regulator, CRP, global DNA-binding factors, StpA and HupB, the antibiotic transporter protein, TolC, and the RtsA/B two-component system (TCS), and validated their post-transcriptional control by SdsR/RyeB RNA.^[3]

See also

• RydB RNA
• RyhB RNA
• RyeE RNA

Notes and References

1. Wassarman KM, Repoila F, Rosenow C, Storz G, Gottesman S . Identification of novel small RNAs using comparative genomics and microarrays . Genes & Development . 15 . 13 . 1637–1651 . July 2001 . 11445539 . 312727 . 10.1101/gad.901001 .
2. Fröhlich KS, Papenfort K, Berger AA, Vogel J . A conserved RpoS-dependent small RNA controls the synthesis of major porin OmpD . Nucleic Acids Research . 40 . 8 . 3623–3640 . April 2012 . 22180532 . 3333887 . 10.1093/nar/gkr1156 .
3. Fröhlich KS, Haneke K, Papenfort K, Vogel J . The target spectrum of SdsR small RNA in Salmonella . Nucleic Acids Research . 44 . 21 . 10406–10422 . December 2016 . 27407104 . 5137417 . 10.1093/nar/gkw632 .