| Ruta del Centro | |
| Date: | April |
| Region: | Mexico |
| Discipline: | Road race |
| Competition: | UCI America Tour |
| Type: | Stage race |
| Number: | 4 (as of 2015) |
| Mostwins: | No repeat winners |
Ruta del Centro is a professional staged cycling race held annually in Mexico. It has been part of the UCI America Tour in category 2.2 since 2013.