| Rupa Karunathilake | |
| Birth Date: | 15 March 1933 |
| Birth Place: | Galle, Sri Lanka |
| Death Place: | Colombo, Sri Lanka |
| Nationality: | Sri Lankan |
| Party: | United National Party |
| Occupation: | Politics |
| Spouse: | Hetumathie née Jayakody |
| Children: | Amal, Sangeeta, Sanjeev |
| Alma Mater: | Ananda Vidyalaya, Elpitiya Mahinda College Galle Nalanda College Colombo |
Lokugamage Rupasena Karunathilake (15 March 1933 – 11 October 2011) (known as Rupa Karunathilake) was a cabinet minister and Member of Parliament representing Bentara-Elpitiya electorate, in Galle District. He was also a Sri Lanka Ambassador to the Netherlands. He was educated at Ananda Vidyalaya, Elpitiya, Mahinda College, Galle and Nalanda College Colombo. His youngest son Sanjeev now Southern Provincial Council Member.