| Rune Nilssen | |
| Birth Date: | 24 October 1975 |
| Birth Place: | Kristiansand, Norway |
| Height: | 1.860NaN0 |
| Position: | Goalkeeper |
| Years1: | 1993–2002 |
| Years2: | 2003–2010 |
| Years3: | 2009 |
| Clubs3: | → F.C. Copenhagen (loan) |
| Caps2: | 77 |
| Caps3: | 0 |
| Goals2: | 0 |
| Goals3: | 0 |
Rune Nilssen (born 24 October 1975) is a Norwegian retired football player.
Nilssen previously played for FK Vigør. He joined Start ahead of the 2003 season. In the autumn 2009, Nilssen was on loan at F.C. Copenhagen, without gaining a single game.