| Rune Frantsen | |
| Birth Date: | 1991 10, df=yes |
| Birth Place: | Denmark |
| Height: | 1.84 m |
| Position: | Full-back |
| Years1: | 2011–2018 |
| Caps1: | 151 |
| Goals1: | 10 |
| Years2: | 2018–2021 |
| Caps2: | 87 |
| Goals2: | 3 |
| Years3: | 2021–2024 |
| Caps3: | 74 |
| Goals3: | 0 |
| Pcupdate: | 17 April 2024 |
Rune Frantsen (born 15 October 1991) is a retired Danish professional footballer who played as a full-back.