| Honorific-Prefix: | Rum |
| Mehmed | |
| Office1: | 14th Grand Vizier of the Ottoman Empire |
| Monarch1: | Mehmed II |
| Term Start1: | 1466 |
| Term End1: | 1469 |
| Predecessor1: | Mahmud Pasha Angelović |
| Successor1: | Ishak Pasha |
| Death Date: | 1470 |
| Death Place: | Istanbul, Ottoman Empire |
| Nationality: | Ottoman |
Rum Mehmed Pasha (Turkish, Ottoman (1500-1928);: روم محمد پاشا; Turkish: Rum Mehmed Paşa; 1466–d. 1470) was an Ottoman statesman, known for being the grand vizier of the Ottoman Empire from 1466 to 1469 and the main rival of Mahmud Pasha Angelović. As his name suggests, he was of Greek descent.[1]
Upon the urging of Karamanlı Mehmet Pasha, Sultan Mehmed II the Conqueror dismissed Rum Mehmed Pasha from office in 1469 and had him executed by drowning in 1470.