Rugulovasine Explained

Rugulovasines are bio-active alkaloids made by Penicillium.[1] Rugulovasine A and B bind strongly to the 5-HT1A, 5-HT2A, and 5-HT2C receptors, but lack meaningful binding affinity towards the α1 adrenergic and dopamine receptors.[2] Little is known about the in vivo activity of Rugulovasine A and B, although they have hypotensive effects in cats.[3]

References

  1. Dorner . JW . Cole . RJ . Hill . R . Wicklow . D . Cox . RH . Penicillium rubrum and Penicillium biforme, new sources of rugulovasines A and B. . Applied and Environmental Microbiology . September 1980 . 40 . 3 . 685–7 . 10.1128/aem.40.3.685-687.1980 . 7425621. 291639 .
  2. Bartoccini . Francesca . Regni . Alessio . Retini . Michele . Piersanti . Giovanni . Asymmetric Total Synthesis of All Rugulovasine Stereoisomers and Preliminary Evaluation of Their Biological Properties . European Journal of Organic Chemistry . 6 May 2022 . 2022 . 17 . 10.1002/ejoc.202200315 . 248080578 . en . 1434-193X. free . 11576/2701930 . free .
  3. Nagaoka . A . Kikuchi . K . Pharmacological studies of new indole alkaloids, rugulovasine A and B hydrochloride. II. Hypotensive mechanism of both alkaloids in the anesthetized cats. . Arzneimittel-Forschung . January 1972 . 22 . 1 . 143–6 . 5066989.

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