| Honorific Prefix: | Saints |
| Rufus and Zosimus | |
| Death Date: | 107 |
| Feast Day: | 18 December |
| Venerated In: | Roman Catholic Church, Eastern Orthodox Churches |
| Death Place: | Rome, Roman Empire |
| Titles: | Martyrs |
Rufus and Zosimus (died 107 AD) are 2nd century Christian martyrs venerated by the Roman Catholic and the Eastern Orthodox churches. They lived in Antioch and were martyred with Ignatius of Antioch during the persecution of Christians under the Roman emperor Trajan.[1] They were killed by beasts in the Roman arena two days before Ignatius suffered the same fate.[2] Their feast day is December 18.[3]