| Rufino | |
| Native Name Lang: | es |
| Settlement Type: | City |
| Map Alt: | Map showing location of Rufino in Argentina |
| Mapframe-Frame-Width: | 270 |
| Mapframe: | yes |
| Mapframe-Caption: | Click on the map for a fullscreen view |
| Mapframe-Zoom: | 12 |
| Pushpin Map: | Argentina |
| Pushpin Map Caption: | Location of Rufino in Argentina |
| Coordinates: | -34.2619°N -62.7114°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Type2: | Department |
| Subdivision Name2: | General López |
| Unit Pref: | Metric |
| Area Total Km2: | 845 |
| Elevation M: | 113 |
| Population Total: | 19211 |
| Population As Of: | 2022 census |
| Population Density Km2: | auto |
| Timezone1: | ART |
| Utc Offset1: | -3 |
| Postal Code Type: | CPA base |
| Postal Code: | S6100 |
| Area Code Type: | Dialing code |
| Area Code: | +54 3382 |
Rufino is a city in the province of Santa Fe, Argentina. It has 19,211 inhabitants as per the . It lies on the southwest of the province, 2600NaN0 from the main metropolitan area of the province Greater Rosario,4160NaN0 from the provincial capital Santa Fe, near the borders with Córdoba (west) and Buenos Aires (south), on the intersection of National Routes 33 and 7.
The town was founded by Gerónimo Segundo Rufino in 1886, as the railway line that linked Diego de Alvear, Santa Fe, to Villa Mercedes, San Luis, was inaugurated. The plans for the new town were approved by the governorship of Santa Fe on 29 March 1889, which is acknowledged as the official foundation date.